Start your designs with the content that goes on the page – not the other way around.
Don’t design “boxes”, “areas”, or “structure” and then fill them out with the content you think will go there.
Instead, start by designing the main elements based on the content that you want to communicate on the page. That way you’ll be sure to include the content right away into your design strategy. Content is what matters most.
Start with the content and how you want to display it. That title, that image, this slogan and that short text. Here goes the navigation, there the main call to action. Here some additional content/options. How do I want to display these elements in order to make sure I will achieve my goals? The rest should follow.